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1

Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy

Carissa F. Santos, John Kurhanewicz, Z. Laura Tabatabai, Jeffry P. Simko, Kayvan R. Keshari, Akpene Gbegnon, Romelyn DeLos Santos, Scot Federman, Katsuto Shinohara, Peter R. Carroll, Christopher M. Ha

Journal:

NMR in Biomedicine

Year:

2010

Language:

english

File:

PDF, 254 KB

english, 2010

2

Hyperpolarization MRI

Miloushev, Vesselin Z., Keshari, Kayvan R., Holodny, Andrei I.

Journal:

Topics in Magnetic Resonance Imaging

Year:

2016

Language:

english

File:

PDF, 11.58 MB

english, 2016

3

Correlation of HR-MAS Spectroscopy Derived Metabolite Concentrations With Collagen and Proteoglycan Levels and Thompson Grade in the Degenerative Disc

Keshari, Kayvan R., Lotz, Jeffrey C., Kurhanewicz, John, Majumdar, Sharmila

Journal:

Year:

2005

Language:

english

File:

PDF, 268 KB

english, 2005

4

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures

Sriram, Renuka, Van Criekinge, Mark, DeLos Santos, Justin, Ahamed, Fayyaz, Qin, Hecong, Nolley, Rosalie, Santos, Romelyn DeLos, Tabatabai, Z. Laura, Bok, Robert A., Keshari, Kayvan R., Vigneron, Danie

Journal:

Year:

2020

File:

PDF, 789 KB

2020

5

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells

Jeong, Sangmoo, Savino, Angela Maria, Chirayil, Rachel, Barin, Ersilia, Cheng, Yuanming, Park, Sun-Mi, Schurer, Alexandra, Mullarky, Edouard, Cantley, Lewis C., Kharas, Michael G., Keshari, Kayvan R.

Journal:

Cell Metabolism

Year:

2021

File:

PDF, 4.67 MB

2021

6

1H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: Inter- and intraobserver reproducibility study

Bonnie N. Joe, Kiarash Vahidi, Andrew Zektzer, Mei-Hsiu Chen, Matthew S. Clifton, Thomas Butler, Kayvan Keshari, John Kurhanewicz, Fergus Coakley, Mark G. Swanson

Journal:

Journal of Magnetic Resonance Imaging

Year:

2008

Language:

english

File:

PDF, 401 KB

english, 2008

7

Imaging of blood flow using hyperpolarized [13C]Urea in preclinical cancer models

Cornelius von Morze, Peder E.Z. Larson, Simon Hu, Kayvan Keshari, David M. Wilson, Jan Henrik Ardenkjaer-Larsen, Andrei Goga, Robert Bok, John Kurhanewicz, Daniel B. Vigneron

Journal:

Journal of Magnetic Resonance Imaging

Year:

2011

Language:

english

File:

PDF, 362 KB

english, 2011

8

Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy

Kayvan R. Keshari, Andrew S. Zektzer, Mark G. Swanson, Sharmila Majumdar, Jeffrey C. Lotz, John Kurhanewicz

Journal:

Magnetic Resonance in Medicine

Year:

2005

Language:

english

File:

PDF, 757 KB

english, 2005

9

Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy

Mark G. Swanson, Andrew S. Zektzer, Z. Laura Tabatabai, Jeffry Simko, Samson Jarso, Kayvan R. Keshari, Lars Schmitt, Peter R. Carroll, Katsuto Shinohara, Daniel B. Vigneron, John Kurhanewicz

Journal:

Magnetic Resonance in Medicine

Year:

2006

Language:

english

File:

PDF, 445 KB

english, 2006

10

Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy

Mark G. Swanson, Kayvan R. Keshari, Z. Laura Tabatabai, Jeffry P. Simko, Katsuto Shinohara, Peter R. Carroll, Andrew S. Zektzer, John Kurhanewicz

Journal:

Magnetic Resonance in Medicine

Year:

2008

Language:

english

File:

PDF, 681 KB

english, 2008

11

Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues

May-Britt Tessem, Mark G. Swanson, Kayvan R. Keshari, Mark J. Albers, David Joun, Z. Laura Tabatabai, Jeffry P. Simko, Katsuto Shinohara, Sarah J. Nelson, Daniel B. Vigneron, Ingrid S. Gribbestad, Joh

Journal:

Magnetic Resonance in Medicine

Year:

2008

Language:

english

File:

PDF, 494 KB

english, 2008

12

Evaluation of the ERETIC method as an improved quantitative reference for 1H HR-MAS spectroscopy of prostate tissue

Mark J. Albers, Thomas N. Butler, Iman Rahwa, Nguyen Bao, Kayvan R. Keshari, Mark G. Swanson, John Kurhanewicz

Journal:

Magnetic Resonance in Medicine

Year:

2009

Language:

english

File:

PDF, 285 KB

english, 2009

13

Hyperpolarized 13C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism

Kayvan R. Keshari, John Kurhanewicz, Rex E. Jeffries, David M. Wilson, Brian J. Dewar, Mark Van Criekinge, Matthew Zierhut, Daniel B. Vigneron, Jeffrey M. Macdonald

Journal:

Magnetic Resonance in Medicine

Year:

2010

Language:

english

File:

PDF, 616 KB

english, 2010

14

Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo

David M. Wilson, Kayvan R. Keshari, Peder E.Z. Larson, Albert P. Chen, Simon Hu, Mark Van Criekinge, Robert Bok, Sarah J. Nelson, Jeffrey M. Macdonald, Daniel B. Vigneron, John Kurhanewicz

Journal:

Journal of Magnetic Resonance

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

15

Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by1H NMR spectroscopy

Brian J. Dewar, Kayvan Keshari, Rex Jeffries, Petras Dzeja, Lee M. Graves, Jeffrey M. Macdonald

Journal:

Year:

2010

Language:

english

File:

PDF, 522 KB

english, 2010

16

In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-13C]alanine

Simon Hu, Minhua Zhu, Hikari A.I. Yoshihara, David M. Wilson, Kayvan R. Keshari, Peter Shin, Galen Reed, Cornelius von Morze, Robert Bok, Peder E.Z. Larson, John Kurhanewicz, Daniel B. Vigneron

Journal:

Magnetic Resonance Imaging

Year:

2011

Language:

english

File:

PDF, 570 KB

english, 2011

17

Solid phase synthesis of hydroxamate peptides for histone deacetylase inhibition

Wilson, David M., Silverman, Lisa N., Bergauer, Markus, Keshari, Kayvan R.

Journal:

Tetrahedron Letters

Year:

2013

Language:

english

File:

PDF, 472 KB

english, 2013

18

A Boronate-Caged [ 18 F]FLT Probe for Hydrogen Peroxide Detection Using Positron Emission Tomography

Carroll, Valerie, Michel, Brian W., Blecha, Joseph, VanBrocklin, Henry, Keshari, Kayvan, Wilson, David, Chang, Christopher J.

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 844 KB

english, 2014

19

A Hydrogen Peroxide-Responsive Hyperpolarized 13 C MRI Contrast Agent

Lippert, Alexander R., Keshari, Kayvan R., Kurhanewicz, John, Chang, Christopher J.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 1.57 MB

english, 2011

20

Hyperpolarized [2- 13 C]-Fructose: A Hemiketal DNP Substrate for In Vivo Metabolic Imaging

Keshari, Kayvan R., Wilson, David M., Chen, Albert P., Bok, Robert, Larson, Peder E. Z., Hu, Simon, Criekinge, Mark Van, Macdonald, Jeffrey M., Vigneron, Daniel B., Kurhanewicz, John

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 4.06 MB

english, 2009

21

Diffusion MR of hyperpolarized 13C molecules in solution

Koelsch, Bertram L., Keshari, Kayvan R., Peeters, Tom H., Larson, Peder E. Z., Wilson, David M., Kurhanewicz, John

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2013

Language:

english

File:

PDF, 313 KB

english, 2013

22

Generating contrast in hyperpolarized 13C MRI using ligand–receptor interactions

Keshari, Kayvan R., Kurhanewicz, John, Macdonald, Jeffrey M., Wilson, David M.

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2012

Language:

english

File:

PDF, 175 KB

english, 2012

23

Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized 13 C metabolites

Koelsch, Bertram L., Reed, Galen D., Keshari, Kayvan R., Chaumeil, Myriam M., Bok, Robert, Ronen, Sabrina M., Vigneron, Daniel B., Kurhanewicz, John, Larson, Peder E. Z.

Journal:

Magnetic Resonance in Medicine

Year:

2014

Language:

english

File:

PDF, 5.31 MB

english, 2014

24

Effect of Oxygen Concentration on Viability and Metabolism in a Fluidized-Bed Bioartificial Liver Using 31 P and 13 C NMR Spectroscopy

Jeffries, Rex E., Gamcsik, Michael P., Keshari, Kayvan R., Pediaditakis, Peter, Tikunov, Andrey P., Young, Gregory B., Lee, Haakil, Watkins, Paul B., Macdonald, Jeffrey M.

Journal:

Tissue Engineering Part C Methods

Year:

2013

Language:

english

File:

PDF, 447 KB

english, 2013

25

Caged [ 18 F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography

Flavell, Robert R., Truillet, Charles, Regan, Melanie K., Ganguly, Tanushree, Blecha, Joseph E., Kurhanewicz, John, VanBrocklin, Henry F., Keshari, Kayvan R., Chang, Christopher J., Evans, Michael J.,

Journal:

Bioconjugate Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

26

Hyperpolarized13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Kayvan R. Keshari, John Kurhanewicz, Robert Bok, Peder E. Z. Larson, Daniel B. Vigneron and David M. Wilson

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.68 MB

english, 2011

27

The Potential of Metabolic Imaging

Gialleonardo, Valentina Di, Wilson, David M., Keshari, Kayvan R.

Journal:

Seminars in Nuclear Medicine

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

28

13C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging

Salamanca-Cardona, Lucia, Keshari, Kayvan R.

Journal:

Cancer & Metabolism

Year:

2015

Language:

english

File:

PDF, 1.99 MB

english, 2015

29

Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor

Keshari, Kayvan R., Wilson, David M., Van Criekinge, Mark, Sriram, Renuka, Koelsch, Bertram L., Wang, Zhen J., VanBrocklin, Henry F., Peehl, Donna M., O'Brien, Tom, Sampath, Deepak, Carano, Richard A.

Journal:

Year:

2015

Language:

english

File:

PDF, 704 KB

english, 2015

30

Metabolic Reprogramming and Validation of Hyperpolarized 13 C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor

Keshari, Kayvan R., Sriram, Renuka, Van Criekinge, Mark, Wilson, David M., Wang, Zhen J., Vigneron, Daniel B., Peehl, Donna M., Kurhanewicz, John

Journal:

Year:

2013

Language:

english

File:

PDF, 3.14 MB

english, 2013

31

ChemInform Abstract: Chemistry and Biochemistry of 13 C Hyperpolarized Magnetic Resonance Using Dynamic Nuclear Polarization

Keshari, Kayvan R., Wilson, David M.

Journal:

Year:

2014

File:

PDF, 18 KB

2014

32

Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor

Sriram, Renuka, Van Criekinge, Mark, Hansen, Ailin, Wang, Zhen J., Vigneron, Daniel B., Wilson, David M., Keshari, Kayvan R., Kurhanewicz, John

Journal:

NMR in Biomedicine

Year:

2015

Language:

english

File:

PDF, 1018 KB

english, 2015

33

Novel Approaches to Imaging Tumor Metabolism

Tee, Sui-Seng, Keshari, Kayvan R.

Journal:

The Cancer Journal

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

34

Lactic Acid and Proteoglycans as Metabolic Markers for Discogenic Back Pain

Keshari, Kayvan R., Lotz, Jeffrey C., Link, Thomas M., Hu, Serena, Majumdar, Sharmila, Kurhanewicz, John

Journal:

Year:

2008

Language:

english

File:

PDF, 414 KB

english, 2008

35

Separation of extra- and intracellular metabolites using hyperpolarized 13C diffusion weighted MR

Koelsch, Bertram L., Sriram, Renuka, Keshari, Kayvan R., Leon Swisher, Christine, Van Criekinge, Mark, Sukumar, Subramaniam, Vigneron, Daniel B., Wang, Zhen J., Larson, Peder E.Z., Kurhanewicz, John

Journal:

Journal of Magnetic Resonance

Year:

2016

Language:

english

File:

PDF, 718 KB

english, 2016

36

High-throughput indirect quantitation of 13C enriched metabolites using 1H NMR

Di Gialleonardo, Valentina, Tee, Sui Seng, Aldeborgh, Hannah N, Miloushev, Vesselin Z., Cunha, Lidia S., Sukenick, George D., Keshari, Kayvan R.

Journal:

Analytical Chemistry

Year:

2016

Language:

english

File:

PDF, 1.41 MB

english, 2016

37

Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

Carney, Brandon, Carlucci, Giuseppe, Salinas, Beatriz, Di Gialleonardo, Valentina, Kossatz, Susanne, Vansteene, Axel, Longo, Valerie A., Bolaender, Alexander, Chiosis, Gabriela, Keshari, Kayvan R., We

Journal:

Molecular Imaging and Biology

Year:

2016

Language:

english

File:

PDF, 1.38 MB

english, 2016

38

Hyperpolarized 13C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1T

Miloushev, Vesselin Z., Di Gialleonardo, Valentina, Salamanca-Cardona, Lucia, Correa, Fabian, Granlund, Kristin L., Keshari, Kayvan R.

Journal:

Journal of Magnetic Resonance

Year:

2017

Language:

english

File:

PDF, 1.90 MB

english, 2017

39

as an endogenous redox sensor for in vivo metabolic imaging

Keshari, Kayvan R, Kurhanewicz, John, Bok, Robert, Larson, Peder E Z, Vigneron, Daniel B, Wilson, David M

Year:

2011

Language:

english

File:

PDF, 5.87 MB

english, 2011

40

Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models

Kossatz, Susanne, Carney, Brandon, Schweitzer, Melanie, Carlucci, Giuseppe, Miloushev, Vesselin Z., Maachani, Uday B., Rajappa, Prajwal, Keshari, Kayvan R., Pisapia, David, Weber, Wolfgang A., Souweid

Journal:

Cancer Research

Year:

2017

File:

PDF, 1.42 MB

2017

41

Multinuclear NMR and MRI reveal an early metabolic response to mTOR inhibition in sarcoma

Di Gialleonardo, Valentina, Aldeborgh, Hannah N., Miloushev, Vesselin, Folkers, Kelly M., Granlund, Kristin, Tap, William D, Lewis, Jason S., Weber, Wolfgang A., Keshari, Kayvan

Journal:

Cancer Research

Year:

2017

Language:

english

File:

PDF, 8.25 MB

english, 2017

42

Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis

Wilson, David M., Di Gialleonardo, Valentina, Wang, Zhen J., Carroll, Valerie, Von Morze, Cornelius, Taylor, Andrew, Sai, Victor, VanCriekinge, Mark, Bok, Robert, Ohliger, Michael A., Keshari, Kayvan

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 980 KB

english, 2017

43

Noninvasive Interrogation of Cancer Metabolism with Hyperpolarized 13 C MRI

Cho, Andrew, Lau, Justin Y.C., Geraghty, Benjamin J., Cunningham, Charles H., Keshari, Kayvan R.

Journal:

Journal of Nuclear Medicine

Year:

2017

Language:

english

File:

PDF, 1.01 MB

english, 2017

44

Imaging and Metabolism || Inflammation and Immune Metabolism

Lewis, Jason S., Keshari, Kayvan R.

Year:

2018

Language:

english

File:

PDF, 439 KB

english, 2018

45

Imaging and Metabolism || Introduction: MRI/MRS as Metabolic Imaging Tools

Lewis, Jason S., Keshari, Kayvan R.

Year:

2018

Language:

english

File:

PDF, 1.40 MB

english, 2018

46

Targeted AKT inhibition in prostate cancer cells and spheroids reduces aerobic glycolysis and generation of hyperpolarized [1- 13 C] lactate

Tee, Sui Seng, Suster, Izabela, Truong, Steven, Jeong, Sangmoo, Eskandari, Roozbeh, Di Gialleonardo, Valentina, Alvarez, Julio A, Aldeborgh, Hannah N, Keshari, Kayvan

Journal:

Molecular Cancer Research

Year:

2018

Language:

english

File:

PDF, 811 KB

english, 2018

47

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes

Qin, Hecong, Carroll, Valerie N., Sriram, Renuka, Villanueva-Meyer, Javier E., von Morze, Cornelius, Wang, Zhen Jane, Mutch, Christopher A., Keshari, Kayvan R., Flavell, Robert R., Kurhanewicz, John,

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.33 MB

english, 2018

48

A non-synthetic approach to extending the lifetime of hyperpolarized molecules using D 2 O solvation

Cho, Andrew, Eskandari, Roozbeh, Miloushev, Vesselin Z., Keshari, Kayvan R.

Journal:

Journal of Magnetic Resonance

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

49

Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy

Lin, Gigin, Keshari, Kayvan R., Park, Jae Mo

Journal:

Contrast Media & Molecular Imaging

Year:

2017

Language:

english

File:

PDF, 6.58 MB

english, 2017

50

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

Kurhanewicz, John, Vigneron, Daniel B., Ardenkjaer-Larsen, Jan Henrik, Bankson, James A., Brindle, Kevin, Cunningham, Charles H., Gallagher, Ferdia A., Keshari, Kayvan R., Kjaer, Andreas, Laustsen, Ch

Journal:

Year:

2019

Language:

english

File:

PDF, 1.39 MB

english, 2019